Integrative Genomic Analyses of Atypical Teratoid Rhabdoid Tumours (ATRTs).
Jonathon Torchia, Daniel Picard, Dong Anh Kwang, Misko Dzamba, King Ching Ho, Seoung-Ki Kim, Louis Louterneau, Lucie Lafay-Cousin, Tiffany SY Chan, Brian Golbourn, Sorana Morrissy, Diane Birks, Claudia Faria, Nicholas Foreman, Xing Fan, Karen Murasko, Anat Epstein, Iris Fried, Helen Toledano, Eugene Hwang, Tarik Tihan, Joanna Phillips, Uhlrich Schuller, Torsten Pietsch, Stefan Pfister, Michael D Taylor, James T Rutka, Alex Judkins, Peter Dirks, Eric Bouffet, Michael Brudno, Jacek Majewski, Cynthia E Hawkins, Nada Jabado, Annie Huang
Abstract
ATRTs (atypical teratoid rhabdoid tumours) represent one of the most aggressive pediatric brain tumours. Despite substantial clinical heterogeneity, ATRTs have been reported to exhibit balanced genomes with only recurrent somatic alterations of the SMARCB1 locus on chr22. To investigate molecular mechanisms underlying clinical heterogeneity in ATRTs, biology we comprehensively interrogated 63 ATRTs using an integrated genomics approach.63 ATRTs were investigated using a combination of OmniQuad ultra-high resolution.
Publication
Cancer Genetics, 207: 447-448, 2014